Inhaled nebulized sodium nitrite decreases pulmonary artery pressure in β-thalassemia patients with pulmonary hypertension.

Kittiphong Paiboonsukwong, Teerapat Yingchoncharoen, Teewin Rakyhao, Suporn Chuncharunee, Piyamitr Sritara, Pavit Pienvichit, Piyadon Sathavorasmith, Kanjana Sirirat, Thanaporn Sriwantana, Sirada Srihirun, Nathawut Sibmooh

Journal: Nitric oxide : biology and chemistry 2019;76():174-178

PMID: 28964835

Full Text on Elsevier Science View on PubMed

Abstract

Pulmonary hypertension is a life-threatening complication in β-thalassemia. Inhaled sodium nitrite has vasodilatory effect on pulmonary vasculature. However, its effect on pulmonary artery pressure (PAP) in β-thalassemia subjects with pulmonary hypertension has never been reported. In this study, we investigated the change in PAP during inhalation of sodium nitrite in 5 β-thalassemia patients. We demonstrated that sodium nitrite administered by nebulization rapidly decreased PAP as measured by echocardiography and right heart catheterization. The effect of nitrite was short as PAP returned to baseline at end of inhalation. Our findings support acute pulmonary vasodilation effect of nitrite in β-thalassemia with pulmonary hypertension.

Address: Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.; Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.; Molecular Medicine Graduate Program, Multidisciplinary Unit, Faculty of Science, Mahidol University, Bangkok, Thailand.; Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.; Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.; Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand. Electronic address: [email protected].

DOI: 10.1016/j.niox.2017.09.010

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MeSH Terms: Administration, Inhalation, Adult, Blood Pressure, Dose-Response Relationship, Drug, Echocardiography, Female, Heart, Humans, Hypertension, Pulmonary, Male, Pulmonary Artery, Sodium Nitrite, beta-Thalassemia