Safety of Contrast Material Use in Children.

Bruno P Soares, Maarten H Lequin, Thierry A G M Huisman

Journal: Magnetic resonance imaging clinics of North America 2018;25(4):779-785

PMID: 28964467

Full Text on Elsevier Science View on PubMed

Abstract

Iodinated and gadolinium-based contrast materials have excellent safety profiles for use in pediatric computed tomography and MR imaging. The rate of acute adverse reactions and contrast-induced nephropathy is lower than in adults. The relationship between nephrogenic systemic fibrosis and gadolinium administration is well established and only a small number of children suffer from this debilitating disorder. The recent finding of gadolinium deposition in the brain of patients with normal renal function has renewed concerns regarding its long-term toxicity. The necessity of gadolinium-based contrast agent use in children should be considered carefully for each examination, and more stable macrocyclic agents should be the primary choice.

Address: Division of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed Tower, Room 4174, Baltimore, MD 21287, USA. Electronic address: [email protected].; Department of Radiology, University Medical Center, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands.; Division of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed Tower, Room 4174, Baltimore, MD 21287, USA.

DOI: 10.1016/j.mric.2017.06.009

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MeSH Terms: Child, Contrast Media, Gadolinium, Humans, Magnetic Resonance Imaging, Nephrogenic Fibrosing Dermopathy, Renal Insufficiency, Chronic, Tomography, X-Ray Computed