Vitamin D receptor gene polymorphisms and the risk of multiple sclerosis: An updated meta-analysis.

Xiao-Long Chen, Ming-Liang Zhang, Lin Zhu, Meng-Le Peng, Fang-Zhou Liu, Guang-Xian Zhang, Li-Mei Wang, Jie Zhao

Journal: Microbial pathogenesis 2018;110():594-602

PMID: 28780323

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

The association between vitamin D receptor (VDR) gene polymorphisms and multiple sclerosis (MS) has been extensively studied, but results were controversial.

METHODS

This meta-analysis aimed to confirm whether VDR gene polymorphisms were associated with MS. Meta-analysis on the association between MS and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allelic contrast, recessive, homozygotes and dominant models. Data were extracted by standardized forms and odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model if the results were heterogeneous. Stratification analysis by the selected study characteristics were performed to detect potential source of heterogeneity.

RESULTS

A total of 21 relevant studies involving 3593 MS patients and 3917 controls were included in the analysis. The association between TaqI polymorphism and MS risk was significant in the homozygous model (p = 0.006) indicated a significant protective effect of TT TaqI genotype. High latitude (40.1-50°N) was also found markedly influenced TaqI polymorphism and MS risk in the recessive and homozygous models (p = 0.045 and p = 0.015, respectively). Additionally, Asian or low latitude (20.1-30°N) people with ApaI homozygous genotype, '> 2013' publication year people in the allele contrast and dominant models of FokI, '> 40 years' age people with BsmI recessive model also indirectly significantly affected the association between VDR gene polymorphisms and MS risk.

CONCLUSION

TaqI polymorphism is a significant protective factor for MS. However, the associations between ApaI, FokI and BsmI polymorphisms and MS were found only by study characteristics.

Address: Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: [email protected].; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Department of Pharmacy, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China. Electronic address: [email protected].; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: [email protected].; Department of Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: [email protected].; Henan Province Traditional Chinese Medicine Research Institute, Zhengzhou, Henan, China. Electronic address: [email protected].; Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: [email protected].; Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: [email protected].; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address: [email protected].

DOI: 10.1016/j.micpath.2017.08.002

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MeSH Terms: DNA Restriction Enzymes, Humans, Multiple Sclerosis, Polymorphism, Genetic, Receptors, Calcitriol, Risk Assessment