Fluorescence Imaging/Agents in Tumor Resection.

Walter Stummer, Eric Suero Molina

Journal: Neurosurgery clinics of North America 2018;28(4):569-583

PMID: 28917285

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Abstract

Intraoperative fluorescence imaging allows real-time identification of diseased tissue during surgery without being influenced by brain shift and surgery interruption. 5-Aminolevulinic acid, useful for malignant gliomas and other tumors, is the most broadly explored compound approved for fluorescence-guided resection. Intravenous fluorescein sodium has recently received attention, highlighting tumor tissue based on extravasation at the blood-brain barrier (defective in many brain tumors). Fluorescein in perfused brain, unselective extravasation in brain perturbed by surgery, and propagation with edema are concerns. Fluorescein is not approved but targeted fluorochromes with affinity to brain tumor cells, in development, may offer future advantages.

Address: Department of Neurosurgery, Univerity Hospital Münster, Münster, Germany. Electronic address: [email protected].; Department of Neurosurgery, Univerity Hospital Münster, Münster, Germany.

DOI: 10.1016/j.nec.2017.05.009

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MeSH Terms: Aminolevulinic Acid, Blood-Brain Barrier, Brain Neoplasms, Fluorescein, Fluorescence, Fluorescent Dyes, Glioma, Humans, Magnetic Resonance Imaging, Interventional