Plasma Glutathione and Prodromal Parkinson's Disease Probability.

Sokratis Charisis, Eva Ntanasi, Maria Stamelou, Georgia Xiromerisiou, Maria Maraki, Aristidis S Veskoukis, Mary Yannakoulia, Mary H Kosmidis, Costas A Anastasiou, Nikolaos Giagkou, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Demetrios Kouretas, Leonidas Stefanis, Nikolaos Scarmeas

Journal: Movement disorders : official journal of the Movement Disorder Society 2022;37(1):200-205

PMID: 34695238

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Abstract

BACKGROUND

A decrease in glutathione (GSH) levels is considered one of the earliest biochemical changes in Parkinson's disease (PD).

OBJECTIVE

The authors explored the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD (pPD) by examining its longitudinal associations with pPD probability trajectories.

METHODS

A total of 405 community-dwelling participants (median age [interquartile range] = 73.2 [7.41] years) without clinical features of parkinsonism were followed for a mean (standard deviation) of 3.0 (0.9) years.

RESULTS

A 1 μmol/L increase in plasma GSH was associated with 0.4% (95% confidence interval [CI], 0.1%-0.7%; P = 0.017) less increase in pPD probability for 1 year of follow-up. Compared with participants in the lowest GSH tertile, participants in the highest GSH tertile had a 12.9% (95% CI, 22.4%-2.2%; P = 0.020) slower rate of increase of pPD probability for 1 year of follow-up.

CONCLUSION

Plasma GSH was associated with pPD probability trajectories; therefore, it might assist in the identification of individuals who are likely to reach the threshold for pPD diagnosis more rapidly. © 2021 International Parkinson and Movement Disorder Society.

Address: 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.; Parkinson's Disease and Movement Disorders Department, HYGEIA Hospital, Athens, Greece.; Department of Neurology, Philipps University, Marburg, Germany.; School of Medicine, University of Thessaly, Larissa, Greece.; Section of Sport Medicine and Biology of Exercise, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece.; Department of Nutrition and Dietetics, School of Health Sciences, Hellenic Mediterranean University, Crete, Greece.; Department of Nutrition and Dietetics, University of Thessaly, Trikala, Greece.; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.; Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Parkinson's Disease and Movement Disorders Department, HYGEIA Hospital, Athens, Greece.; Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.; Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece.; Department of Biochemistry-Biotechnology, University of Thessaly, Larisa, Greece.; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, the Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.

DOI: 10.1002/mds.28826

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MeSH Terms: Aged, Glutathione, Humans, Parkinson Disease, Probability, Prodromal Symptoms