Fatty acid profile of maternal and fetal erythrocytes and placental expression of fatty acid transport proteins in normal and intrauterine growth restriction pregnancies.

Renata P Assumpção, Daniela B Mucci, Fernanda C P Fonseca, Henrique Marcondes, Fátima L C Sardinha, Marta Citelli, Maria G Tavares do Carmo

Journal: Prostaglandins, leukotrienes, and essential fatty acids 2018;125():24-31

PMID: 28987718

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Abstract

Long-chain polyunsaturated fatty acids (LC-PUFA), mainly docosahexaenoic (DHA) and arachidonic acids (AA), are critical for adequate fetal growth and development. We investigated mRNA expression of proteins involved in hydrolysis, uptake and/or transport of fatty acids in placenta of fifteen full term normal pregnancies and eleven pregnancies complicated by intrauterine growth restriction (IUGR) with normal umbilical blood flows. The mRNA expression of LPL, FATPs (-1, -2 and -4) and FABPs (-1 and -3) was increased in IUGR placentas, however, tissue profile of LC-PUFA was not different between groups. Erythrocytes from both mothers and fetuses of the IUGR group showed lower concentrations of AA and DHA and inferior DHA/ALA ratio compared to normal pregnancies (P < 0.05). We hypothesize that reduced circulating levels of AA and DHA could up-regulate mRNA expression of placental fatty acids transporters, as a compensatory mechanism, however this failed to sustain normal LC-PUFA supply to the fetus in IUGR.

Address: Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; Departamento de Nutrição Básica e Experimental, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: [email protected].

DOI: 10.1016/j.plefa.2017.08.011

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MeSH Terms: Adult, Erythrocytes, Fatty Acid Transport Proteins, Fatty Acid-Binding Proteins, Fatty Acids, Female, Fetal Growth Retardation, Humans, Lipoprotein Lipase, Maternal-Fetal Exchange, Placenta, Pregnancy, RNA, Messenger, Young Adult