RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction.

Danyan Chen, Xiaolong Huang, Song Lu, Huacong Deng, Hua Gan, Xiaogang Du, Tang Weixue

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2018;125(8):547-553

PMID: 28704853

Full Text on Georg Thieme Verlag Stuttgart, New York View on PubMed

Abstract

To investigate the RBP4/Lp-PLA/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI). One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. The degrees of cognitive dysfunction were evaluated. Serum RBP4 concentrations were determined by ELISA and protein expressions of Lp-PLA and Netrin-1 were determined by Western Blot. Compared with NSCI group, the cognitive function of patients in SCI group was impaired, the concentrations of RBP4 and the expressions of Lp-PLA and Netrin-1 increased (P<0.05). RBP4 concentrations were positively correlated with the cognitive dysfunction of SCI patients. Moreover, there existed a regression correlation between them. RBP4 may be used as a predictive factor of diabetic nephropathy patients complicated with SCI and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI.

Address: Departments of Endocrinology & Nephrology, the Chongqing General Hospital, Chongqing, China.; Departments of Neurosurgery, No. 324 Hospital of PLA, Chongqing, China.; Departments of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Departments of Nephrology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Departments of Pathophysiology, Basic Medical College, Chongqing Medical University, Chongqing, China.

DOI: 10.1055/s-0043-109099

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MeSH Terms: 1-Alkyl-2-acetylglycerophosphocholine Esterase, Aged, Cerebral Infarction, Cognitive Dysfunction, Diabetic Nephropathies, Female, Humans, Male, Middle Aged, Netrin-1, Retinol-Binding Proteins, Plasma, Signal Transduction