Genome-wide association study identifies inversion in the locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Address: Department of Internal Medicine I, Martin Luther University, Halle, Germany.; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany.; Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.; Leipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Department of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Paediatric Nutritional Medicine, Technische Universität München (TUM), Freising, Germany.; Institute of Human Genetics, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany.; Department of Internal Medicine I, Martin Luther University, Halle, Germany.; Institut National de la Santé et de la Recherche Médicale (INSERM) U1078; Etablissement Français du Sang (EFS) - Bretagne; Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale; Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Régional Universitaire (CHRU) Brest, Hôpital Morvan, Brest, France.; Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology, University of Leipzig, Leipzig, Germany.; Department of Gastroenterology, Technische Universität München (TUM), Munich, Germany.; Department of Gastroenterology & Hepatology, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands.; Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg, Mannheim, Germany.; LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.; Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University - San Raffaele Scientific Institute, Milan, Italy.; Department of Gastroenterology, Medical University of Lublin, Lublin, Poland.; Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.; Division of Nephrology and Dialysis, Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Chirurgische Klinik, Erlangen, Germany.; Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.; Institute for Translational Medicine and First Department of Internal Medicine, University of Pécs, Pécs, Hungary.; HAS-SZTE, Momentum Gastroenterology Multidisciplinary Research Group, Szeged, Hungary.; Department of Internal Medicine and Gastroenterology, University of Medicine and Pharmacy, Craiova, Romania.; Department of Gastroenterology and Internal Medicine, Medical University Bialystok, Bialystok, Poland.; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.; TIB MOLBIOL, Berlin, Germany.; Pôle des Maladies de l'Appareil Digestif, Service de Gastroentérologie-Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, France.; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE- Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Gastrocentrum, Karolinska Institutet CLINTEC, Stockholm, Sweden.; Department of Biology and Medical Genetics, University Hospital Motol and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.; Grupo de Epidemiología Genética y Molecular Programa de Genética del Cáncer Humano Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.; CIBERONC, Spain.; Department of Digestive Tract Diseases, Medical University of Łódź, Łódź, Poland.; Biology and Genetics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.; Department of Medicine II, University Hospital,Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Gastroenterology and Hepatology, Radboud umc, Nijmegen, The Netherlands.; Department of Internal Medicine, Salem Medical Centre and Centre for Alcohol Research, University of Heidelberg, Heidelberg, Germany.; Department of Pediatrics I, Medical University, Innsbruck, Austria.; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Medical and Surgical Sciences, IV Surgical Clinic, University of Padua, Padua, Italy.; Division of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Clinic for Internal Medicine, Hospital Döbeln, Döbeln, Germany.; CIBERONC, Spain.; Epithelial Carcinogenesis Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.; Department of Psychiatry, University of Regensburg, Regensburg, Germany.; Department of Gastroenterology, Hepatology, Infectious Diseases, Medical Faculty of Mannheim University of Heidelberg, Mannheim, Germany.; Department of Surgery, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Psychiatric Hospital, University of Munich, Munich, Germany.; Department of Surgery and Interventional Science, University College London, London, UK.; Department of Gastroenterology and Hepatology, University Hospital of Zürich, Zürich, Switzerland.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Leipzig University Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology, University of Leipzig, Leipzig, Germany.; Department of Internal Medicine, Neurology and Dermatology, Division of Endocrinology, University of Leipzig, Leipzig, Germany.; Department of General, Visceral, and Transplant Surgery, Ludwig Maximilian University, Munich, Germany.; Division of Gastroenterology, Tohoku University Graduate School of Medicine, SendaiMiyagi, Japan.