Four new cases of pediatric thoracic aortic aneurysm (TAA) with review of the molecular genetic basis, utilizing the newly published consensus nomenclature.

Shriprasad Deshpande, Adina Alazraki, Nasim Khoshnam, Diana Kantarovich, Pooya Hoseinzadeh, Camden Hebson, Ajay Bhatia, Lauren Schaffer, Elana Maccou, Bahig M Shehata

Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2018;31():34-40

PMID: 28886442

Full Text on Elsevier Science View on PubMed

Abstract

The majority of thoracic aortic aneurysms (TAA) in the pediatric population are due to post repair etiology (iatrogenic). Although rare, underlying inheritable disease and congenital cardiac anomalies represent the most common non-iatrogenic cause of TAA among patients in this age group (1-21 years of age). Herein, we present a case series of 9aortic aneurysms with varying underlying etiology. We discuss the molecular genetic basis of these syndromes in conjunction with the radiological findings and histological description utilizing the newly published consensus criteria article.

Address: Emory University School of Medicine, Department of Pediatric Cardiology, Atlanta, GA, USA.; Emory University School of Medicine, Department of Pediatric Radiology, Atlanta, GA, USA.; Emory University School of Medicine, Department of Pediatric Pathology, Atlanta, GA, USA.; Emory University School of Medicine, Department of Pediatric Pathology, Atlanta, GA, USA. Electronic address: [email protected].

DOI: 10.1016/j.carpath.2017.07.005

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MeSH Terms: Aortic Aneurysm, Thoracic, Aortic Coarctation, Cutis Laxa, Eye Abnormalities, Female, Humans, Infant, Infant, Newborn, Loeys-Dietz Syndrome, Neurocutaneous Syndromes, Terminology as Topic