Role of Wnt5a in the Pathogenesis of Inflammatory Diseases.

Mehran Pashirzad, Mojtaba Shafiee, Farzad Rahmani, Reihane Behnam-Rassouli, Fatemeh Hoseinkhani, Mikhail Ryzhikov, Maryam Moradi Binabaj, Mohammad Reza Parizadeh, Amir Avan, Seyed Mahdi Hassanian

Journal: Journal of cellular physiology 2017;232(7):1611-1616

PMID: 27859213

Full Text on Wiley View on PubMed

Abstract

Wnt5a initiates pro-inflammatory responses through activation of non-canonical Wnt signaling pathway. Pro-inflammatory functions of Wnt5a trigger pro-inflammatory signaling cascades and increase secretion of pro-inflammatory cytokines and chemokines. Wnt5a as a potent signaling molecule is strongly implicated in a number of diseases including cancer, diabetes, metabolic disorders, and of special interest in this review, inflammatory diseases. This review summarizes the role of Wnt5a in the pathogenesis of inflammatory diseases including atherosclerosis, rheumatoid arthritis, psoriasis vulgaris and sepsis, promoting greater understanding, and clinical management of these diseases. J. Cell. Physiol. 232: 1611-1616, 2017. © 2016 Wiley Periodicals, Inc.

Address: Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.; Department of Medical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, Saint Louis, Missouri.; Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Departments of Medical Oncology and Neurology, VU University Medical Center, Amsterdam, The Netherlands.; Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.1002/jcp.25687

Link outs

Free resources

Other Literature Sources:

https://scite.ai/reports/27859213

Subscription / membership required

Full Text Sources:

https://doi.org/10.1002/jcp.25687

MeSH Terms: Humans, Inflammation, Models, Biological, Wnt Proteins, Wnt Signaling Pathway