A randomized controlled trial of a new treatment for labor dystocia.

Eva Wiberg-Itzel, Susan Wray, Helena Åkerud

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2018;31(17):2237-2244

PMID: 28587493

Abstract

OBJECTIVE

Labor dystocia is an intransigent, high-profile issue in obstetric care. Amniotic fluid lactate (AFL) reflects the uterine metabolic status. High levels associate with subsequent need for operative intervention due to dystocia. In sports medicine, it is known that lactic acid can affect muscular performance and can be decreased by bicarbonate given orally before physical activity.

MATERIAL AND METHODS

Two hundred dystocic deliveries were included. At the confirmation of dystocia, the AFL-level was analyzed. Deliveries were randomized to an intake of bicarbonate or not. In the "non-bicarbonate-group", stimulation with oxytocin was started immediately. In the "bicarbonate-group", bicarbonate was given; and oxytocin was started 1 hour after the intake. New sampling of AF was performed after 1 hour in both groups.

OUTCOME MEASURED

if an oral intake of bicarbonate changes the AFL levels and enhances delivery outcome in dystocic deliveries.

RESULTS

Bicarbonate decreases the AFL levels (p < .001). The spontaneous vaginal delivery rate after treatment with bicarbonate was increased (p = .007), without affecting the fetal outcome.

CONCLUSIONS

An increase of spontaneous vaginal deliveries resulted from bicarbonate ingestion by dystocic women. A decreased level of AFL-level was shown. This simple, low cost treatment has the potential to improve maternal morbidity and satisfaction worldwide.

Address: a Department of Obstetrics and Gynecology , Sodersjukhuset , Stockholm , Sweden.; b Department of Clinical Science and Education, Section of Obstetrics and Gynaecology , Karolinska Institutet , Sodersjukhuset , Sweden.; c Department of Molecular and Cellular Physiology , Institute of Translational Medicine, University of Liverpool , Liverpool , UK.; d Department of Immunology, Genetics and Pathology , Uppsala University , Uppsala , Sweden.
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