Arterial function parameters in patients with metabolic syndrome and severe hypertriglyceridemia.

Egidija Rinkūnienė, Eglė Butkutė, Roma Puronaitė, Žaneta Petrulionienė, Vilma Dženkevičiūtė, Vytautas Kasiulevičius, Aleksandras Laucevičius

Journal: Journal of clinical lipidology 2018;11(4):901-907

PMID: 28595894

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Hypertriglyceridemia (hTG) is 1 of the dyslipidemia manifestations in patients with metabolic syndrome (MetS). However, for several decades, the role of hTG in cardiovascular risk was not well established.

OBJECTIVE

The aim of this study was to assess the parameters of the vascular structure and function in patients with MetS and different degree of hTG.

METHODS

Patients (aged 40-65 years) with MetS were divided into 3 groups by triglyceride (TG) levels according to National Cholesterol Education Program Adult Treatment Panel III Guidelines: severe hTG (TG ≥ 500 mg/dL), moderate hTG (TG 200-499 mg/dL), and a control (TG < 150 mg/dL) groups. Noninvasive assessment of vascular parameters (aortic augmentation index adjusted for heart rate 75 bpm [AixHR75], pulse wave velocity [PWV], flow-mediated dilatation, and common carotid artery intima-media thickness (IMT)) were performed.

RESULTS

Among the 1938 patients analyzed, 1041 had hTG. Moderate hTG was observed in 90.40% (n = 941), whereas severe TG was observed in 9.6% (n = 100) of patients. Overall TG concentration was 231.17 ± 184.23 mg/dL; in severe hTG group, TG concentration was 795.36 ± 368.45 mg/dL, in moderate hTG group 285.20 ± 70.86 mg/dL, and 112.48 ± 24.80 mg/dL in control group. AIxHR75 and IMT were the lowest in the severe hTG group (P < .001 for both). Mean arterial pressure, carotid-radial PWV (9.25 ± 1.13 vs 9.24 ± 1.28 vs 8.91 ± 1.28; P < .001) as well as carotid-femoral PWV (8.63 ± 1.65 vs 8.75 ± 1.58 vs 8.51 ± 1.6; P = .006) were the higher in hTG groups compared with control. There were no significant differences between groups in flow-mediated dilatation (3.39 ± 2.01 vs 3.26 ± 2.43 vs 3.45 ± 2.61, P = .283).

CONCLUSIONS

Patients with MetS and severe hTG have lower IMT and AIxHR75 and higher PWV and mean arterial pressure. Many factors could affect arterial parameters, and more research are needed to investigate arterial parameters and hTG connection.

Address: Department of Cardiovascular Medicine, Vilnius University, Vilnius, Lithuania; Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania; Experimental and Clinical Medicine Research Institute, Vilnius University, Vilnius, Lithuania. Electronic address: [email protected].; Vilnius University Medical Faculty, Vilnius, Lithuania.; Department of Cardiovascular Medicine, Vilnius University, Vilnius, Lithuania; Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.; Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania; Vilnius University Medical Faculty, Vilnius, Lithuania.; Department of Cardiovascular Medicine, Vilnius University, Vilnius, Lithuania; Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania; Experimental and Clinical Medicine Research Institute, Vilnius University, Vilnius, Lithuania.

DOI: 10.1016/j.jacl.2017.04.119