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The pancreatic cancer microenvironment: A true double agent.

Laleh G Melstrom, Marcela D Salazar, Don J Diamond

Journal: Journal of surgical oncology 2017;116(1):7-15

PMID: 28605029

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Abstract

The tumor microenvironment in pancreatic cancer is a complex balance of pro- and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy, and Vitamin D. The developing clinical therapeutics will be reviewed.

© 2017 Wiley Periodicals, Inc.

Address: Department of Surgery and Experimental Therapeutics, City of Hope National Medical Center, Duarte, California.; Department of Experimental Therapeutics, City of Hope National Medical Center, Duarte, California.
DOI: 10.1002/jso.24643

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MeSH Terms: Adenocarcinoma, Angiogenesis Inhibitors, Angiotensin II Type 1 Receptor Blockers, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cancer-Associated Fibroblasts, Carcinogenesis, Cell Transformation, Neoplastic, Clinical Trials as Topic, Connective Tissue Growth Factor, Focal Adhesion Protein-Tyrosine Kinases, Hedgehog Proteins, Humans, Hyaluronic Acid, Immunotherapy, Macrophages, Myeloid Cells, Neutrophils, Osteonectin, Pancreatic Neoplasms, Pancreatic Stellate Cells, Tumor Microenvironment, Vitamin D
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