Dietary Management of Skin Health: The Role of Genistein.

Natasha Irrera, Gabriele Pizzino, Rosario D'Anna, Mario Vaccaro, Vincenzo Arcoraci, Francesco Squadrito, Domenica Altavilla, Alessandra Bitto

Journal: Nutrients 2018;9(6):622

PMID: 28629129

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Abstract

In women, aging and declining estrogen levels are associated with several cutaneous changes, many of which can be reversed or improved by estrogen supplementation. Two estrogen receptors-α and β-have been cloned and found in various tissue types. Epidermal thinning, declining dermal collagen content, diminished skin moisture, decreased laxity, and impaired wound healing have been reported in postmenopausal women. Experimental and clinical studies in postmenopausal conditions indicate that estrogen deprivation is associated with dryness, atrophy, fine wrinkling, and poor wound healing. The isoflavone genistein binds to estrogen receptor β and has been reported to improve skin changes. This review article will focus on the effects of genistein on skin health.

Address: Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy. [email protected].; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy. [email protected].; Department of Human Pathology, University of Messina, Messina 98125, Italy. [email protected].; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy. [email protected].; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy. [email protected].; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy. [email protected].; Department of Biomedical Sciences, Dentistry and Morphological and Functional Images, University of Messina, Messina 98125, Italy. [email protected].; Department of Clinical and Experimental Medicine, University of Messina, Messina 98125, Italy. [email protected].

DOI: 10.3390/nu9060622

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MeSH Terms: Female, Genistein, Humans, Postmenopause, Skin, Skin Aging