Recent perspectives of molecular aberrations in pediatric high-grade glioma.

Zhengwei Li, Qingzeng Sun, Yingchun Shi

Journal: Minerva pediatrica 2021;72(2):116-122

PMID: 28643992

Full Text on Minerva Medica View on PubMed

Abstract

Pediatric high-grade glioma (HGG), including diffuse intrinsic pontine glioma (DIPG) are highly aggressive tumors with no effective cures. Lack of understanding of the molecular biology of these tumors, in part due to lack of well-characterized pre-clinical models, is a great challenge in the development of novel therapies. Recent studies have shown that pediatric HGG short-term cell cultures retain many of the tumor characteristics in vivo and at present one of the best choices for in-vivo experimental studies. The present review article would put light on novel genetic and epigenetic changes in pediatric HGG that might, act as a gold standard potential biomarkers and/or therapeutic targets in near future.

Address: Department of Pediatric Surgery, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.; Department of Pediatric Surgery, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China - [email protected].

DOI: 10.23736/S0026-4946.17.04823-X