Adverse Reactions to Transfusion of Blood Products and Best Practices for Prevention.

Susan K Frazier, Jacob Higgins, Andrew Bugajski, Allison R Jones, Michelle R Brown

Journal: Critical care nursing clinics of North America 2017;29(3):271-290

PMID: 28778288

Full Text on Elsevier Science View on PubMed

Abstract

Transfusion, a common practice in critical care, is not without complication. Acute adverse reactions to transfusion occur within 24 hours and include acute hemolytic transfusion reaction, febrile nonhemolytic transfusion reaction, allergic and anaphylactic reactions, and transfusion-related acute lung injury, transfusion-related infection or sepsis, and transfusion-associated circulatory overload. Delayed transfusion adverse reactions develop 48 hours or more after transfusion and include erythrocyte and platelet alloimmunization, delayed hemolytic transfusion reactions, posttransfusion purpura, transfusion-related immunomodulation, transfusion-associated graft versus host disease, and, with long-term transfusion, iron overload. Clinical strategies may reduce the likelihood of reactions and improve patient outcomes.

Address: PhD Program, RICH Heart Program, College of Nursing, University of Kentucky, CON Building, Office 523, 751 Rose Street, Lexington, KY 40536-0232, USA. Electronic address: [email protected].; College of Nursing, University of Kentucky, CON Building, 751 Rose Street, Lexington, KY 40536-0232, USA.; Department of Acute, Chronic & Continuing Care, School of Nursing, University of Alabama at Birmingham, NB 543, 1720 2nd Avenue South, Birmingham, AL 35294-1210, USA.; Clinical Laboratory Science, University of Alabama at Birmingham, SHPB 474, 1705 University Boulevard, Birmingham, AL 35294, USA.

DOI: 10.1016/j.cnc.2017.04.002

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MeSH Terms: Acute Lung Injury, Critical Care Nursing, Erythrocytes, Evidence-Based Medicine, Humans, Transfusion Reaction