Population Survey of Iodine Deficiency and Environmental Disruptors of Thyroid Function in Young Children in Haiti.

CONTEXT

Iodine deficiency is the leading cause of preventable neurodevelopmental delay in children worldwide and a possible public health concern in Haiti.

OBJECTIVE

To determine the prevalence of iodine deficiency in Haitian young children and its influence by environmental factors.

DESIGN

Cross-sectional study, March through June 2015.

SETTING

Community churches in 3 geographical regions in Haiti.

PARTICIPANTS

299 healthy Haitian children aged 9 months to 6 years; one-third each enrolled in a coastal, mountainous, and urban region.

MAIN OUTCOME MEASURES

Urinary iodide, serum thyrotropin (TSH), goiter assessment, and urinary perchlorate and thiocyanate.

RESULTS

Mean age was 3.3±1.6 years, with 51% female, median family income USD 30/week, and 16% malnutrition. Median urinary iodide levels were normal in coastal (145 μg/L, interquartile range [IQR] 97 to 241) and urban regions (187 μg/L, IQR 92 to 316), but revealed mild iodine deficiency in a mountainous region (89 μg/L, IQR 56 to 129), P < 0.0001. Grade 1 goiters were palpated in 2 children, but TSH values were normal. Urinary thiocyanate and perchlorate concentrations were not elevated. Predictors of higher urinary iodide included higher urinary thiocyanate and perchlorate, breastfeeding, and not living in a mountainous region.

CONCLUSIONS

Areas of mild iodine deficiency persist in Haiti's mountainous regions. Exposure to two well-understood environmental thyroid function disruptors is limited.

Copyright © 2017 by the Endocrine Society