What Have We Learned from the Genetics of Hypertension?

Friedrich C Luft

Journal: The Medical clinics of North America 2017;101(1):195-206

PMID: 27884229

Full Text on Elsevier Science View on PubMed

Abstract

Twin studies show that about half the risk of hypertension development is inherited. Mendelian hypertension has elucidated astounding basic pathways contributing to hypertension over (presumably) dietary salt intake or directly through increased peripheral vascular resistance. The Mendelian mutations exercise large effects on blood pressure. Inversely, studying the entire human genome for sources signaling blood pressure has yielded many signals with small effects. Thus far, few loci have been validated or translated into targets. Both genetic strategies are necessary, and much remains to be done.

Address: Charité Medical Faculty, Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine, Lindenbergerweg 80, Berlin 13125, Germany. Electronic address: [email protected].

DOI: 10.1016/j.mcna.2016.08.015

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MeSH Terms: Blood Pressure, Epigenesis, Genetic, Genome-Wide Association Study, Humans, Hypertension, Mutation, Twin Studies as Topic