CDPKs and 14-3-3 Proteins: Emerging Duo in Signaling.

Mélanie Ormancey, Patrice Thuleau, Christian Mazars, Valérie Cotelle

Journal: Trends in plant science 2017;22(3):263-272

PMID: 28065409

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Abstract

Calcium-dependent protein kinases (CDPKs) are Ca-sensors that play pivotal roles in plant development and stress responses. They have the unique ability to directly translate intracellular Ca signals into reversible phosphorylation events of diverse substrates which can mediate interactions with 14-3-3 proteins to modulate protein functions. Recent studies have revealed roles for the coordinated action of CDPKs and 14-3-3s in regulating diverse aspects of plant biology including metabolism, development, and stress responses. We review here the underlying interaction and cross-regulation of the two signaling proteins, and we discuss how this insight has led to the emerging concept of CDPK/14-3-3 signaling modules that could contribute to response specificity.

Address: Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France.; Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France. Electronic address: [email protected].

DOI: 10.1016/j.tplants.2016.11.007

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MeSH Terms: 14-3-3 Proteins, Gene Expression Regulation, Plant, Plant Proteins, Protein Kinases, Signal Transduction