Back to the future: Immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain.

George H Lowell, Sagit Ziv, Svetlana Bruzil, Ron Babecoff, Tamar Ben-Yedidia

Journal: Vaccine 2017;35(5):713-715

PMID: 28065476

Full Text on Elsevier Science View on PubMed

Abstract

We previously reported a 2011/12 study in elderly showing that immunization with the universal influenza vaccine candidate, M-001, three weeks before administering trivalent influenza vaccine (TIV) enhanced seroconversion of Hemagglutination Inhibition (HAI) antibodies against known influenza vaccine strains circulating at that time. We now report that those subjects primed with M-001 prior to TIV in 2011 also showed, in their 2011 sera, significantly more HAI antibodies with improved seroprotection and seroconversion against strain A/Switzerland/9715293/2013(H3N2-like) that caused the 2014/15 influenza epidemic and that wasn't known to circulate in 2011/12. These data indicate that M-001 can provide broadened enhanced immunity extending even to influenza strains destined to circulate in future years. The fact that M-001 stimulates T cell activation and is devoid of HA hypervariable epitopes indicates that such broadened HAI responses effected by M-001 priming is due to extensive T cell priming.

Address: BiondVax Pharmaceuticals Ltd., 14 Einstein St., Ness Ziona 7414002, Israel.; BiondVax Pharmaceuticals Ltd., 14 Einstein St., Ness Ziona 7414002, Israel. Electronic address: [email protected].

DOI: 10.1016/j.vaccine.2016.12.063

Link outs

Free resources

Medical:

https://medlineplus.gov/vaccines.html

Other Literature Sources:

Subscription / membership required

Full Text Sources:

MeSH Terms: Adjuvants, Immunologic, Aged, Aged, 80 and over, Aluminum Compounds, Antibodies, Neutralizing, Antibodies, Viral, Cross Protection, Female, Hemagglutination Inhibition Tests, Humans, Immunization, Immunization Schedule, Immunogenicity, Vaccine, Influenza A Virus, H3N2 Subtype, Influenza Vaccines, Influenza, Human, Male, Phosphates, T-Lymphocytes, Vaccines, Subunit