Recent advances in biotechnological applications of alcohol dehydrogenases.

Yu-Guo Zheng, Huan-Huan Yin, Dao-Fu Yu, Xiang Chen, Xiao-Ling Tang, Xiao-Jian Zhang, Ya-Ping Xue, Ya-Jun Wang, Zhi-Qiang Liu

Journal: Applied microbiology and biotechnology 2017;101(3):987-1001

PMID: 28074225

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Abstract

Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze the interconversion between alcohols and aldehydes or ketones with high stereoselectivity under mild conditions. ADHs are widely employed as biocatalysts for the dynamic kinetic resolution of racemic substrates and for the preparation of enantiomerically pure chemicals. This review provides an overview of biotechnological applications for ADHs in the production of chiral pharmaceuticals and fine chemicals.

Address: Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China. [email protected].; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China.; Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, People's Republic of China. [email protected].

DOI: 10.1007/s00253-016-8083-6

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https://dx.doi.org/10.1007/s00253-016-8083-6

MeSH Terms: Alcohol Dehydrogenase, Alcohols, Aldehydes, Biocatalysis, Biotechnology, Ketones, Stereoisomerism, Technology, Pharmaceutical