Four decades of ocular renin-angiotensin and kallikrein-kinin systems (1977-2017).

Rajko Igić

Journal: Experimental eye research 2018;166():74-83

PMID: 28549900

Full Text on Elsevier Science View on PubMed

Abstract

This review offers a contemporary history of the renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems with emphasis on how these complex systems affect the eye. It describes the types of communication (cross-talk) between the two systems and evaluates their potential role in the development of diabetic retinopathy, diabetic macular edema, age-related macular degeneration, glaucoma, and uveitis. In addition to detailing the important physiological actions of components of the RAS and KKS, possibilities are suggested for new therapeutic avenues in the treatment of common ocular diseases. Historical notes indicate the major events in this research area, marking four decades from the first publication on the discovery of renin and angiotensin converting enzyme in the eye to the present time.

Address: Department of Anesthesiology and Pain Management, Stroger Hospital of Cook County, Chicago, IL 60612, USA; Department of Pharmacology, University of Banjaluka, 78000 Banjaluka, Republic of Srpska, Bosnia and Herzegovina; Academy of Arts and Sciences, Republic of Srpska, 7800 Banjaluka, Bosnia and Herzegovina. Electronic address: [email protected].

DOI: 10.1016/j.exer.2017.05.007

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MeSH Terms: Glaucoma, Humans, Kallikrein-Kinin System, Receptor Cross-Talk, Renin-Angiotensin System, Retinal Diseases, Uveitis