Pathophysiology of ventricular tachyarrhythmias : From automaticity to reentry.

Andres Enriquez, David S Frankel, Adrian Baranchuk

Journal: Herzschrittmachertherapie & Elektrophysiologie 2018;28(2):149-156

PMID: 28567491

Abstract

Ventricular arrhythmias are a heterogeneous group of arrhythmias and may arise in patients with cardiomyopathy or structurally normal hearts. The electrophysiologic mechanisms responsible for the initiation and maintenance of ventricular tachycardia include enhanced automaticity, triggered activity, and reentry. Differentiating between these three mechanisms can be challenging and usually requires an invasive electrophysiology study. Establishing the underlying mechanism in a particular patient is helpful to define the optimal therapeutic approach, including the selection of pharmacologic agents or delineation of an ablation strategy.

Address: Section of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Heart Rhythm Service, Kingston General Hospital, Queen's University, Kingston, ON, Canada. [email protected].

DOI: 10.1007/s00399-017-0512-4

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https://dx.doi.org/10.1007/s00399-017-0512-4

MeSH Terms: Calcium, Calcium Channels, L-Type, Cardiomyopathies, Electrocardiography, Epicardial Mapping, Heart Conduction System, Humans, Potassium, Prognosis, Risk Factors, Sodium, Sodium-Calcium Exchanger, Tachycardia, Atrioventricular Nodal Reentry, Tachycardia, Sinoatrial Nodal Reentry, Tachycardia, Ventricular