Fast and slow Ca-dependent hyperpolarization mechanisms connect membrane potential and sleep homeostasis.

Koji L Ode, Takahiro Katsumata, Daisuke Tone, Hiroki R Ueda

Journal: Current opinion in neurobiology 2018;44():212-221

PMID: 28575719

Full Text on Elsevier Science View on PubMed

Abstract

Several lines of evidence indicate that the sleep-wake state of cortical neurons is regulated not only through neuronal projections from the lower brain, but also through the cortical neurons' intrinsic ability to initiate a slow firing pattern related to the slow-wave oscillation observed in electroencephalography of the sleeping brain. Theoretical modeling and experiments with genetic and pharmacological perturbation suggest that ion channels and kinases acting downstream of calcium signaling regulate the cortical-membrane potential and sleep duration. In this review, we introduce possible Ca-dependent hyperpolarization mechanisms in cortical neurons, in which Ca signaling associated with neuronal excitation evokes kinase cascades, and the activated kinases modify ion channels or pumps to regulate the cortical sleep/wake firing mode.

Address: Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.; Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.; Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Synthetic Biology, RIKEN Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: [email protected].

DOI: 10.1016/j.conb.2017.05.007

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MeSH Terms: Brain Waves, Electroencephalography, Homeostasis, Humans, Membrane Potentials, Neurons, Potassium Channels, Calcium-Activated, Sleep