JCL roundtable: Future of the lipid laboratory: Using the laboratory to manage the patient (part 2).

William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris

Journal: Journal of clinical lipidology 2018;11(4):846-854

PMID: 28642100

Abstract

The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published. The clinical laboratory has evolved to provide more focused information with measures that can help us assess risk and target our therapy more effectively. In this roundtable discussion, I had the opportunity to talk with physicians who consider lipoprotein management to be central features of their practice every day. They personally care for patients with metabolic disorders in which the lipoproteins have caused disease or are predicted to do so. They are well-versed on the way that science is leading us in our field. I believe that you will learn from their view of current needs regarding lipoprotein measures and the changes that may derive from ongoing scientific studies in our field.

Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Address: Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: [email protected].; Department of Internal Medicine, Metabolic Institute of America, Tarzana, CA, USA.; Department of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Internal Medicine, Medical University of South Carolina, Charleston, SC, USA.
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