Primary and Secondary Chemoprevention of Malignant Melanoma.

Jessica Mounessa, Talayesa Buntinx-Krieg, Rosie Qin, Cory A Dunnick, Robert P Dellavalle

Journal: American journal of clinical dermatology 2017;17(6):625-634

PMID: 27665299

Abstract

The incidence of malignant melanoma (MM) continues to rise in the United States. While sun protection and full body skin examinations remain the mainstay of preventative care, chemoprevention of the deadly disease has become an increasingly popular field of study. In this focused review, we discuss current findings and analyze the risks and benefits of various agents investigated for the primary and secondary chemoprevention of MM. Such agents include topical retinoids, vitamins, and supplements, Polypodium leucotomas extracts, non-steroidal anti-inflammatory agents (NSAIDs), statins, sunscreens, and field therapy with topical imiquimod for primary and secondary chemoprevention. We further identify a need for expanded high quality human research on the topic.

Address: Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, NY, 11794, USA.; Department of Dermatology, University of Colorado Hospital, 1665 Aurora Ct, Aurora, CO, 80045, USA.; University of Central Florida College of Medicine, 6850 Lake Nona Blvd, Orlando, FL, 32827, USA.; Department of Medicine, University of San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.; Department of Dermatology, Denver VA Medical Center, 1055 Clermont St. #165, Denver, CO, 80220, USA.; Department of Dermatology, University of Colorado Hospital, 1665 Aurora Ct, Aurora, CO, 80045, USA. [email protected].; Department of Dermatology, Denver VA Medical Center, 1055 Clermont St. #165, Denver, CO, 80220, USA. [email protected].

DOI: 10.1007/s40257-016-0221-5

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https://dx.doi.org/10.1007/s40257-016-0221-5

MeSH Terms: Adjuvants, Immunologic, Anti-Inflammatory Agents, Non-Steroidal, Chemoprevention, Clinical Studies as Topic, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Incidence, Melanoma, Micronutrients, Plant Extracts, Polypodium, Skin Neoplasms, Sunscreening Agents, Treatment Outcome, United States, Melanoma, Cutaneous Malignant