The potential role of oxytocin and perinatal factors in the pathogenesis of autism spectrum disorders - review of the literature.

Melinda Vanya, Szabina Szucs, Agnes Vetro, Gyorgy Bartfai

Journal: Psychiatry research 2017;247():288-290

PMID: 27974283

Abstract

Autism Spectrum Disorders (ASD) are characterized by: social and communication impairments, and by restricted repetitive behaviors. The aim of the present paper is to review abnormalities of oxytocin (OXT) and related congenital malformations in ASD. A literature search was conducted in the PubMed database up to 2016 for articles related to the pathomechanism of ASD, abnormalities of OXT and the OXT polymorphism in ASD. The pathomechanism of ASD has yet to be. The development of ASD is suggested to be related to abnormalities of the oxytocin-arginin-vasopressin system. Previous results suggest that OXT and arginine vasopressin (AVP) may play a role in the etiopathogenesis of ASD.

Address: Department of Obstetrics and Gynaecology, Albert Szent-Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary; KF TFK Health Research and Health Promotion Research Group, Kecskemet, Hungary. Electronic address: [email protected].; Division of Adolescent Psychiatry, Department of Paediatrics, Albert Szent-Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary.; Department of Obstetrics and Gynaecology, Albert Szent-Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary.

DOI: 10.1016/j.psychres.2016.12.007

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MeSH Terms: Autism Spectrum Disorder, Female, Folic Acid, Humans, Infant, Low Birth Weight, Infant, Newborn, Male, Neurophysins, Polymorphism, Single Nucleotide, Pregnancy, Premature Birth, Prenatal Exposure Delayed Effects, Protein Precursors, Receptors, Oxytocin, Vasopressins