Pathophysiology of Non Alcoholic Fatty Liver Disease.

Salvatore Petta, Amalia Gastaldelli, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti, Ferruccio Bonino

Journal: International journal of molecular sciences 2017;17(12):2082

PMID: 27973438

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Abstract

The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.

Address: Gastroenterology, Di.Bi.M.I.S Policlinic Paolo Giaccone Hospital, University of Palermo, PC 90127, Palermo, Italy. [email protected].; Cardiometabolic Risk Unit-Institute of Clinical Physiology, CNR, PC 56124, Pisa, Italy. [email protected].; Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy. [email protected].; Gastroenterology and Hepatology, Department of Medical Sciences, Città della, Salute e della Scienza di Torino Hospital, University of Turin, PC 10122, Turin, Italy. [email protected].; Department of Nephrology, Urology and Renal Transplant-Fondazione IRCCS Ca', Granda, PC 20122 Milano, Italy. [email protected].; Institute of Internal Medicine, Gastroenterology and Liver Diseases Unit, Fondazione Policlinico Gemelli, Catholic University of Rome, PC 00168, Rome, Italy. [email protected].; Department of Gastroenterology 1 and Obesity 2, Polytechnic University of Marche, PC 60121, Ancona, Italy. [email protected].; Metabolic Liver Diseases-Università degli Studi Milano-Fondazione IRCCS Ca', Granda via F Sforza 35, PC 20122 Milano, Italy. [email protected].; Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy. [email protected].; Institute for Health, PC 53042, Chianciano Terme, Italy. [email protected].

DOI: 10.3390/ijms17122082

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https://medlineplus.gov/fattyliverdisease.html

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https://scite.ai/reports/27973438

MeSH Terms: Adipose Tissue, Gastrointestinal Hormones, Humans, Lipids, Muscles, Non-alcoholic Fatty Liver Disease, Pancreatic Hormones