Extracellular functions of 14-3-3 adaptor proteins.

Andrew Kaplan, Mardja Bueno, Alyson E Fournier

Journal: Cellular signalling 2017;31():26-30

PMID: 27993556

Full Text on Elsevier Science View on PubMed

Abstract

14-3-3s are a family of adaptor proteins with a wide range of roles in cell signaling. Although they are primarily localized within the cytosol, 14-3-3s are also known to be present in the extracellular environment. Externalization of 14-3-3 can occur as a result of cell death or physiologically via release in exosomes. Interesting biological activities with relevance for tissue homeostasis and disease are now being described for extracellular 14-3-3s. Moreover, aminopeptidase N (APN) has been identified as a cell surface receptor for 14-3-3s. Here we review the array of bioactivities that have been ascribed to extracellular 14-3-3s and discuss applications as biomarkers and as targets for drug development.

Address: Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Québec, H3A 2B4, Canada. Electronic address: [email protected].; Department of Neurology and Neurosurgery, Montréal Neurological Institute, McGill University, Montréal, Québec, H3A 2B4, Canada.

DOI: 10.1016/j.cellsig.2016.12.007