Complement 3 serum levels as a pro-inflammatory biomarker for insulin resistance in obesity.

Reem M Al Haj Ahmad, Hayder A Al-Domi

Journal: Diabetes & metabolic syndrome 2018;11 Suppl 1():S229-S232

PMID: 28017633

Full Text on Elsevier Science View on PubMed

Abstract

INTRODUCTION

Obesity is frequently characterized by chronic inflammation and insulin resistance (IR). Obesity-associated inflammation is responsible for the complement system activation of which the third component (C3) plays the central role.

OBJECTIVE

to discuss several aspects of the central component of the complement system in relation to obesity and obesity-associated IR.

METHODS

A critical review of the relevant published English articles from 2003- 2014 was carried out using several search engines including PubMed, Google Scholar, and ScienceDirect. Keywords were used, including complement system, C3, obesity-induced inflammation, IR, ASP, and adipose tissue.

CONCLUSION

The defect in the adipose tissue secretory function during obesity may result in different metabolic disorders including IR. The C3 role during obesity-associated inflammation in IR is emerging. More longitudinal studies are warranted to evaluate the role of C3 among other pro-inflammatory biomarkers for IR.

Address: Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Queen Rania Street, Amman 11942, Jordan. Electronic address: [email protected].; Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Queen Rania Street, Amman 11942, Jordan. Electronic address: [email protected].

DOI: 10.1016/j.dsx.2016.12.036