Review: Effects of maternal micronutrient supplementation on placental function.

Kerry Richard, Olivia Holland, Kelly Landers, Jessica J Vanderlelie, Pierre Hofstee, James S M Cuffe, Anthony V Perkins

Journal: Placenta 2018;54():38-44

PMID: 28031147

Full Text on Elsevier Science View on PubMed

Abstract

Pregnancy is a physiological challenge that may require additional nutritional support. Suboptimal micronutrient intakes and micronutrient deficiencies during pregnancy are a global problem, often leading to poor maternal and child outcomes. Micronutrient supplementation is commonly recommended during pregnancy to support and enhance maternal metabolism. Recent studies suggest that the use of multiple micronutrient supplements may be of benefit during a normal pregnancy and may significantly reduce the risk of preeclampsia, preterm delivery, gestational diabetes, and improve pregnancy outcomes. Given the crucial role that the placenta plays in mediating pregnancy outcomes, it is important to consider the impact of micronutrient supplementation on the mechanisms associated with placental function, as well as maternal and fetal homeostasis. This review will consider the role of key micronutrients in supporting pregnancy and the possible mechanisms by which multiple micronutrients influence placental function and modulate placental oxidative stress and inflammation.

Address: Conjoint Endocrine Laboratory, Chemical Pathology, Pathology Queensland, Queensland Health, Herston, Qld 4029, Australia; School of Medicine, University of Queensland, Herston, Qld 4029, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Qld 4000, Australia.; School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, Australia. Electronic address: [email protected].; Conjoint Endocrine Laboratory, Chemical Pathology, Pathology Queensland, Queensland Health, Herston, Qld 4029, Australia.; School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, Australia.

DOI: 10.1016/j.placenta.2016.12.022

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MeSH Terms: Dietary Supplements, Female, Humans, Micronutrients, Placenta, Pregnancy, Prenatal Nutritional Physiological Phenomena