Circadian disruption of ICU patients: A review of pathways, expression, and interventions.

Anna Korompeli, Olav Muurlink, Nadia Kavrochorianou, Theodoros Katsoulas, George Fildissis, George Baltopoulos

Journal: Journal of critical care 2017;38():269-277

PMID: 28012425

Full Text on Elsevier Science View on PubMed

Abstract

Intensive care unit patients typically exhibit pathologic wakefulness, poor quality of daytime sleep, nocturnal sleep fragmentation, and sleep patterns that feature the absence of slow wave sleep and rapid eye movement. This article offers a review of the existing literature examining circadian desynchronization in critically ill patients, highlighting contributing factors identified by scholars, and circadian abnormalities observed in these patients. It discusses potential implications for clinical practice and suggests avenues of future research. Elucidating the role of circadian rhythms in the management of critical illness can guide future chronotherapeutic approaches and optimize patient outcomes.

Address: National and Kapodistrian University of Athens, School of Health Sciences, ICU Research Unit at "Agioi Anargyroi" General Hospital, Greece.; Central Queensland University, Brisbane, Griffith Institute of Educational Research, Brisbane, Australia.; National and Kapodistrian University of Athens, School of Health Sciences, ICU Research Unit at "Agioi Anargyroi" General Hospital, Greece. Electronic address: [email protected].

DOI: 10.1016/j.jcrc.2016.12.006

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MeSH Terms: Chronobiology Disorders, Circadian Rhythm, Clinical Alarms, Critical Care, Critical Illness, Humans, Intensive Care Units, Light, Melatonin, Noise, Nutritional Support, Respiration, Artificial, Sleep, Sleep Deprivation, Sleep, REM