Role of selectins and their ligands in human implantation stage.

Ying Feng, Xue Ma, Liwen Deng, Bin Yao, Ying Xiong, Yilun Wu, Lin Wang, Qianhong Ma, Fang Ma

Journal: Glycobiology 2017;27(5):385-391

PMID: 28115423

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Abstract

Selectins are a family of calcium-dependent, type I transmembrane, carbohydrate-binding glycoproteins. Selectins and their ligands are not only involved in physiological processes such as leukocyte homing and pathological processes such as cancer, but also play an essential role in the human implantation. L-selectin and its ligands participate in the adhesion of the blastocyst to the endometrium at the maternal-fetal interface. P-selectin and E-selectin are involved in immune recognition of maternal decidua to the embedded embryo as well as trophoblast migration within decidual spiral arterioles. Moreover, altered expression of selectins and their ligands are found to be associated with some abnormal pregnancies and infertilities. This review focuses on the current progress of research on the role of selectins and their ligands in the human implantation process.

Address: Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.; West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China.; Department of Pediatric Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.; Department of Biology, San Diego State University, San Diego, CA 92182, USA.; School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77225, USA.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan610041, P.R. China.; Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan610041, P.R. China.; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

DOI: 10.1093/glycob/cwx009

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MeSH Terms: Decidua, Embryo Implantation, Endometrium, Female, Humans, Ligands, Male, Pregnancy, Selectins, Trophoblasts