Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals.

Lauren Stone, Steven K Grinspoon, Georges El-Fakhri, Kenneth C Williams, Udo Hoffmann, Thomas Brady, Bonnie Abbruzzese, Fred Cope, Amanda Martin, Markella V Zanni, Borek Foldyna, Patrick Autissier, Joshua Walker, Tricia H Burdo, Michael T Lu, Moses Q Wilks, Mabel Toribio

Journal: The Journal of infectious diseases 2017;215(8):1264-1269

PMID: 28204544

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Abstract

BACKGROUND

The ability to noninvasively assess arterial CD206+ macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease.

METHODS

We trialed a novel macrophage-specific arterial imaging technique.

RESULTS

We demonstrated colocalization between technetium Tc 99m tilmanocept (99mTc-tilmanocept) and CD206+ macrophages ex vivo. In vivo application of 99mTc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99mTc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P = .009). Among all subjects, aortic high-level 99mTc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status.

CONCLUSION

These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV.

CLINICAL TRIALS REGISTRATION

NCT02542371.

Address: Program in Nutritional Metabolism and.; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston.; Cardiac MR PET CT Program, and.; Biology Department, Boston College, Chestnut Hill, Massachusetts.; Navidea Biopharmaceuticals, Dublin, Ohio.

DOI: 10.1093/infdis/jix095

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MeSH Terms: Aorta, Atherosclerosis, Case-Control Studies, Cross-Sectional Studies, Dextrans, HIV Infections, Humans, Lectins, C-Type, Lymph Nodes, Macrophages, Male, Mannans, Mannose Receptor, Mannose-Binding Lectins, Middle Aged, Plaque, Atherosclerotic, Radiopharmaceuticals, Receptors, Cell Surface, Regression Analysis, Single Photon Emission Computed Tomography Computed Tomography, Technetium Tc 99m Pentetate, United States