The role of the vaginal microbiome in gynaecological cancer.

M Champer, A M Wong, J Champer, I L Brito, P W Messer, J Y Hou, J D Wright

Journal: BJOG : an international journal of obstetrics and gynaecology 2019;125(3):309-315

PMID: 28278350

Abstract

UNLABELLED

Human microbiome research has shown commensal bacteria to be a major factor in both wellness and disease pathogenesis. Interest in the microbiome has recently expanded beyond the gut to include a multitude of other organ systems for which the microbiome may have health implications. Here, we review the role of the vaginal microbiome in health and disease, with a particular focus on gynaecologic malignancies. Further, we suggest that it may be possible to expand the use of probiotics in the treatment of gynaecological cancers.

TWEETABLE ABSTRACT

A review of the research to date on the relation between the vaginal microbiome and gynaecological cancers.

Address: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA.; Department of Computer Science and Center for Computational Molecular Biology, Brown University, Providence, RI, USA.; Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, USA.; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

DOI: 10.1111/1471-0528.14631

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https://doi.org/10.1111/1471-0528.14631

MeSH Terms: Female, Genital Neoplasms, Female, Humans, Microbiota, Probiotics, Vagina, Women's Health