A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective.

Valery V Wojciechowski, Daniela Calina, Konstantinos Tsarouhas, Alexander V Pivnik, Alexander A Sergievich, Vladimir V Kodintsev, Ekaterina A Filatova, Eren Ozcagli, Anca Oana Docea, Andreea Letitia Arsene, Eliza Gofita, Christina Tsitsimpikou, Aristidis M Tsatsakis, Kirill S Golokhvast

Journal: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2017;25(1):10

PMID: 28416008

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Abstract

Physicians often come across with cases of vitamin K antagonists-dependent coagulopathy for reasons such as accidental use of the vitamin K antagonists (VKA), excessive administration of prescribed anticoagulants of indirect action or not reported administration of vitamin K antagonists due to memory impairment and/or other mental disorders, even deliberate use thereof (attempt to murder or suicide). Rodenticide-poisoning (coumarins, warfarins) via food or occupational accidents are difficult to diagnose. This article discusses different types of acquired vitamin K-dependent coagulopathy. Differential diagnosis is primarily based on patient statements before additional causes of vitamin K deficiency are explored. Even when pathological vitamin K deficiency is not determined, appropriate and urgent medical treatment is necessary: administration of fresh frozen plasma or concentrated factors of the prothrombin complex, administration of vitamin K remedies along with symptomatic therapy. With early diagnosis and prescription of appropriate therapy, prognosis is favorable. Reasons for vitamin K antagonists-dependent coagulopathy cases.

Address: Department of Hospital Therapy and Pharmacology, Amur State Medical Academy, 675000, Blagoveshchensk, Russia.; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares, 200349, Craiova, Romania.; Cardiological Department, University Hospital of Larissa, Larissa, Greece.; Department of Hematology-Oncology and Secondary Immunodeficient Diseases, D.D. Pletnev Moscow Clinical Research and Practical Centre of Health Department, 111123, Moscow, Russia.; School of Arts, Culture and Sports, Far Eastern Federal University, 690022, Vladivostok, Russia.; School of Biomedicine, Far Eastern Federal University, 690022, Vladivostok, Russia.; Department of Hematology, Amur Regional Clinical Hospital, 675000, Blagoveshchensk, Russia.; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.; Department of Toxicology, University of Medicine and Pharmacy of Craiova, Petru Rares, 200349, Craiova, Romania.; Department of Pharmaceutical Microbiology, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6, TraianVuia Street, sector 2, 020956, Bucharest, Romania.; Department of Hazardous Substances, General Chemical State Laboratory of Greece, Mixtures & Articles, 16 An. Tsocha Str, Athens, 115121, Greece.; SEC Nanotechnology, Far Eastern Federal University, 690022, Vladivostok, Russia. [email protected].; Forensic Sciences and Toxicology Department, Medical School, University of Crete, P.O. Box 1393, 71003, Heraklion, Crete, Greece. [email protected].; Scientific Educational Center of Nanotechnology, Federal Scientific Center of Hygiene, Far Eastern Federal University, F.F. Erisman, Moscow, 690950, Russian Federation. [email protected].; SEC Nanotechnology, Far Eastern Federal University, 690022, Vladivostok, Russia. [email protected].

DOI: 10.1186/s40199-017-0175-z