Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation.

L M Knowles, J A Milner

Journal: The Journal of nutrition 2001;131(3s):1061S-6S

PMID: 11238817

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Both oil- and water-soluble allyl sulfur compounds from garlic have been found to possess antitumorigenic properties. These antitumorigenic properties increase as exposure increases both in vitro and in vivo. Generally, oil-soluble allyl sulfur compounds are more effective antiproliferative agents than their water-soluble counterparts. The ability of these compounds to suppress proliferation is associated with a depression in cell cycle progression and the induction of apoptosis. This depression in cell division coincides with an increase in the percentage of cells blocked in the G(2)/M phase of the cell cycle. A depression in p34(cdc2) kinase may account for this blockage in cell division.

Address: Graduate Program in Nutrition and the Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA.

DOI: 10.1093/jn/131.3.1061S

Link outs

Free resources

Miscellaneous:

https://assays.cancer.gov/CPTAC-797

Subscription / membership required

Full Text Sources:

MeSH Terms: Allyl Compounds, Antineoplastic Agents, Apoptosis, Cell Cycle, Cell Division, Cell Transformation, Neoplastic, Cyclin-Dependent Kinases, Garlic, Neoplasms, Plants, Medicinal, Protein Serine-Threonine Kinases, Sulfides, Tumor Cells, Cultured, Cyclin-Dependent Kinase-Activating Kinase