Metabolic and Endocrine Considerations After Burn Injury.

Felicia N Williams, David N Herndon

Journal: Clinics in plastic surgery 2018;44(3):541-553

PMID: 28576243

Full Text on Elsevier Science View on PubMed

Abstract

Severe burn injury is followed by a profound hypermetabolic response that persists up to 2 years after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and glucagon that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, control of infection, early and continuous enteral nutrition, and pharmacologic treatments aimed at mitigating physiologic derangements have markedly decreased morbidity.

Address: Department of Surgery, North Carolina Jaycee Burn Center, University of North Carolina, Chapel Hill, 3007D Burnett Womack Building, CB 7206, Chapel Hill, NC 27599-7206, USA.; Department of Surgery, Shriners Hospital of Children, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA. Electronic address: [email protected].

DOI: 10.1016/j.cps.2017.02.013

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MeSH Terms: Body Temperature Regulation, Burns, Catecholamines, Energy Metabolism, Humans