Relapsing polychondritis associated with psoriasis vulgaris successfully treated with adalimumab: A case report with published work review.

Haruka Matsuo, Akihiko Asahina, Takeshi Fukuda, Yoshinori Umezawa, Hidemi Nakagawa

Journal: The Journal of dermatology 2018;44(7):826-829

PMID: 28266051

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Abstract

Relapsing polychondritis (RP) is a rare autoimmune-mediated disease characterized by inflammation involving cartilaginous tissues. We report here a case of RP in a 38-year-old Japanese man with 13-year duration of psoriasis vulgaris treated with topical steroids and vitamin D . The patient presented with tender swelling and erythema of both auricles, and the antibody to type II collagen was detected. The biopsy specimen revealed a dense mixed cell infiltration over the auricular cartilage. We reviewed eight cases with the association of RP and psoriasis, and in all cases the clinical course of psoriasis did not correlate with that of RP. The severity of RP was mild in the majority of cases, and our case was unique in that the patient had no joint symptoms. Adalimumab treatment was effective for both RP and psoriasis. Fat-suppressed contrast-enhanced magnetic resonance imaging was beneficial, not only to demonstrate subclinical inflammation in the nasal septum, but also to subjectively assess the improvement of RP.

Address: Departments of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.; Departments of Radiology, The Jikei University School of Medicine, Tokyo, Japan.

DOI: 10.1111/1346-8138.13796

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MeSH Terms: Adalimumab, Administration, Cutaneous, Adult, Antirheumatic Agents, Autoantibodies, Autoimmune Diseases, Biopsy, C-Reactive Protein, Cholecalciferol, Collagen Type II, Ear Cartilage, Glucocorticoids, Humans, Magnetic Resonance Imaging, Male, Matrix Metalloproteinase 3, Polychondritis, Relapsing, Psoriasis, Severity of Illness Index