Facile Synthesis of a MoS-Prussian Blue Nanocube Nanohybrid-Based Electrochemical Sensing Platform for Hydrogen Peroxide and Carcinoembryonic Antigen Detection.

Herein, an electrochemical detection platform was designed based on a Prussian blue nanocube-decorated molybdenum disulfide (MoS-PBNCs) nanocomposite. Shape-controlled and high-dispersion PBNCs were supported on the MoS nanosheet surface, which would be simply controlled by varying the experimental conditions. Expectedly, such obtained MoS-based nanocomposites possessed excellent electrocatalytic ability, which could be employed to construct an electrochemical sensor for nonenzymatic hydrogen peroxide (HO) detection. More interestingly, MoS-PBNCs nanocomposites could be utilized to construct a sensor for label-free detection of carcinoembryonic antigen (CEA). The electrochemical response of the MoS-based immunosensor was linear with the CEA concentration ranging from 0.005 to 10 ng mL. Moreover, the detection limit was calculated to be 0.54 pg mL. The acceptable selectivity and high stability made such immunosensors detect CEA in human serum with satisfactory results. All data indicated that this MoS-PBNCs nanocomposite may be a promising electrochemical sensing platform for the detection of chemical and biological molecules.