A Case of Salicylate Intoxication Complicated by Coagulopathy, Pulmonary Edema, and Pancreatitis.

Itay Ayalon, Matthew Noble Alder, Travis Ryan Langner, Einar Thor Hafberg, Alexander Gerhard Miethke, Jennifer Melissa Kaplan

Journal: American journal of therapeutics 2017;23(6):e1929-e1932

PMID: 26938763

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Abstract

The large availability of salicylic acid products makes them an often encountered source of poisoning in the emergency department. Even though in most cases the prognosis is good, with a low incidence of long-term morbidity and mortality, complications do occur, and some of those can be life threatening. We present an unusual case of salicylate intoxication in an adolescent in which several uncommon complications (severe coagulopathy, pulmonary edema, and pancreatitis) conjoined together. We review the literature and discuss the complications pathogenesis and differential diagnosis. We suggest that these potentially life-threatening complications be acknowledged, investigated, and rapidly treated.

Address: 1Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH; and 2Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.

DOI: 10.1097/MJT.0000000000000385

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MeSH Terms: Acidosis, Adolescent, Alkalosis, Respiratory, Antifibrinolytic Agents, Azotemia, Blood Coagulation Disorders, Female, Fluid Therapy, Humans, Hypocalcemia, Hyponatremia, Hypoxia, Oxygen Inhalation Therapy, Pancreatitis, Plasma, Pulmonary Edema, Salicylic Acid, Vitamin K