Review: Traumatic brain injury and hyperglycemia, a potentially modifiable risk factor.

Jia Shi, Bo Dong, Yumin Mao, Wei Guan, Jiachao Cao, Rongxing Zhu, Suinuan Wang

Journal: Oncotarget 2018;7(43):71052-71061

PMID: 27626493

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Abstract

Hyperglycemia after severe traumatic brain injury (TBI) occurs frequently and is associated with poor clinical outcome and increased mortality. In this review, we highlight the mechanisms that lead to hyperglycemia and discuss how they may contribute to poor outcomes in patients with severe TBI. Moreover, we systematically review the proper management of hyperglycemia after TBI, covering topics such as nutritional support, glucose control, moderated hypothermia, naloxone, and mannitol treatment. However, to date, an optimal and safe glycemic target range has not been determined, and may not be safe to implement among TBI patients. Therefore, there is a mandate to explore a reasonable glycemic target range that can facilitate recovery after severe TBI.

Address: Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.

DOI: 10.18632/oncotarget.11958

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MeSH Terms: Blood Glucose, Brain, Brain Injuries, Traumatic, Diuretics, Osmotic, Glucose, Humans, Hyperglycemia, Hypoglycemic Agents, Hypothermia, Induced, Insulin, Intracranial Hypertension, Mannitol, Naloxone, Risk Factors