Pregnancy in fanconi anaemia with bone marrow failure: a case report and review of the literature.

Flavia Sorbi, Federico Mecacci, Alessandro Di Filippo, Massimiliano Fambrini

Journal: BMC pregnancy and childbirth 2017;17(1):53

PMID: 28158987

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Abstract

BACKGROUND

Fanconi anaemia is a rare inherited disease characterized by congenital abnormalities, progressive bone marrow failure and predisposition to malignancy. Successful pregnancies in transplanted patients have been reported. In this paper we will describe the pregnancy of a patient with Fanconi anaemia without transplantation.

CASE PRESENTATION

A 34-year-old nulliparous woman with Fanconi anaemia was referred to our institution. Pregnancy was complicated by progressive pancytopenia and two severe infections. C-section was performed at 36 weeks. Both infant and mother are well.

CONCLUSION

Successful pregnancy in a Fanconi anaemia patient with bone marrow failure is possible. The mode of delivery in patients with bone marrow failure should be determined by obstetric indications. The case highlights the safe outcome of the pregnancy with strict clinical and laboratory control by a multidisciplinary team.

Address: Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy. [email protected].; Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Viale Morgagni 85, 50134, Florence, Italy.; Department of Health Sciences - Division of Anaesthesiology, University of Florence, Careggi University Hospital, Florence, Italy.

DOI: 10.1186/s12884-017-1236-5

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https://medlineplus.gov/bonemarrowdiseases.html

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https://scite.ai/reports/28158987

MeSH Terms: Adult, Anti-Bacterial Agents, Bacteremia, Bone Marrow Diseases, Campylobacter Infections, Cesarean Section, Diabetes, Gestational, Diet, Diabetic, Erythrocyte Transfusion, Escherichia coli Infections, Fanconi Anemia, Female, Humans, Hypoglycemic Agents, Insulin, Neutropenia, Pancytopenia, Platelet Transfusion, Pregnancy, Pregnancy Complications, Hematologic, Pregnancy Complications, Infectious, Puerperal Infection, Staphylococcal Infections, Thrombocytopenia