Englerins: A Comprehensive Review.

Zhenhua Wu, Senzhi Zhao, David M Fash, Zhenwu Li, William J Chain, John A Beutler

Journal: Journal of natural products 2017;80(3):771-781

PMID: 28170253

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Abstract

In the decade since the discovery of englerin A (1) and its potent activity in cancer models, this natural product and its analogues have been the subject of numerous chemical, biological, and preclinical studies by many research groups. This review summarizes published findings and proposes further research directions required for entry of an englerin analogue into clinical trials for kidney cancer and other conditions.

Address: Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.

DOI: 10.1021/acs.jnatprod.6b01167

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https://doi.org/10.1021/acs.jnatprod.6b01167

MeSH Terms: Antineoplastic Agents, Phytogenic, Humans, Kidney Neoplasms, Molecular Structure, Sesquiterpenes, Guaiane