Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects.

Martin Purpura, Ryan P Lowery, Jacob M Wilson, Haider Mannan, Gerald Münch, Valentina Razmovski-Naumovski

Journal: European journal of nutrition 2018;57(3):929-938

PMID: 28204880

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Abstract

PURPOSE

The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO).

METHODS

Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period.

RESULTS

CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC) in comparison with the unformulated StdC.

CONCLUSION

The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans.

Address: Increnovo LLC, 2138 E Lafayette Pl, Milwaukee, WI, 53202, USA.; Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL, 33606, USA.; Centre for Health Research, School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.; National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia. [email protected].; Molecular Medicine Research Group, School of Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia. [email protected].; National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW, 2560, Australia.; South Western Sydney Clinical School, School of Medicine, The University of New South Wales, Sydney, NSW, 2052, Australia.

DOI: 10.1007/s00394-016-1376-9

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MeSH Terms: Adult, Antineoplastic Agents, Phytogenic, Antioxidants, Area Under Curve, Cohort Studies, Cross-Over Studies, Curcumin, Diarylheptanoids, Dietary Supplements, Double-Blind Method, Female, Food Additives, Food Handling, Humans, Intestinal Absorption, Male, Nutritive Value, Young Adult, gamma-Cyclodextrins