Lutropin receptor function: insights from natural, engineered, and computer-simulated mutations.

F Fanelli, A P Themmen, D Puett

Journal: IUBMB life 2002;51(3):149-55

PMID: 11547916

Abstract

The lutropin receptor is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimer glycoprotein hormone family. As reviewed herein, comparative analyses of natural, engineered, and computer-simulated mutations of the lutropin receptor have provided considerable insight into the molecular basis of receptor function.

Address: Department of Chemistry, University of Modena and Reggio Emilia, Modena, Italy.

DOI: 10.1080/152165401753544214

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https://onlinelibrary.wiley.com/doi/10.1080/152165...

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https://clinicaltrials.gov/search?term=AREA%5BRefe...

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Amino Acid Sequence, Computer Simulation, Female, Humans, Male, Models, Molecular, Molecular Sequence Data, Mutation, Protein Engineering, Protein Structure, Tertiary, Receptors, LH