Autoimmune gastritis: relationships with anemia and Helicobacter pylori status.

Vincenzo Villanacci, Giovanni Casella, Francesco Lanzarotto, Camillo Di Bella, Angelo Sidoni, Moris Cadei, Tiziana Salviato, Maria Pina Dore, Gabrio Bassotti

Journal: Scandinavian journal of gastroenterology 2017;52(6-7):674-677

PMID: 28276835

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Abstract

BACKGROUND

Autoimmune gastritis (AIG) is a gastric pathologic condition affecting the mucosa of the fundus and the body and eventually leading to hypo-achlorhydria.

AIMS

We report our clinical and pathological experience with AIG.

METHODS

Data from patients with a diagnosis of AIG seen in the period January 2002-December 2012 were retrieved. Only patients with complete sets of biopsies were analyzed.

RESULTS

Data from 138 patients were available for analysis. Pernicious anemia was present in 25% of patients, iron deficiency anemia was found in 29.7% of patients, hypothyroidism in 23% of patients, type 1 diabetes in 7.9% of patients, and vitiligo in 2.8% of patients. Parietal cell antibodies were positive in 65% of patients, and no patient had serology positive for celiac disease. All gastric biopsies showed glandular atrophy associated with enterochromaffin-like (ECL)-cells hyperplasia, features limited to the mucosa of the fundus and body, and focal glandular intestinal metaplasia. Helicobacter pylori was negative in all cases.

CONCLUSIONS

AIG was strongly associated with anemia; atrophy, intestinal metaplasia and ECL hyperplasia in the gastric fundus and body are hallmarks of this condition.

Address: a Pathology Section, Department of Molecular and Translational Medicine , Spedali Civili and University of Brescia , Brescia , Italy.; c Department of Medicine , Desio Hospital, Monza and Brianza , Italy.; b Gastroenterology Section, 1st Medical Clinic, Spedali Civili and University of Brescia , Brescia , Italy.; d Department of Clinical Pathology , Desio Hospital, Monza and Brianza , Italy.; e Pathology Section, Department of Experimental Medicine , University of Perugia School of Medicine , Perugia, Perugia , Italy.; f Pathology Institute, Azienda Ospedaliera Universitaria, Ospedali Riuniti di Trieste , Trieste , Italy.; g Department of Clinical and Experimental Medicine , University of Sassari , Sassari , Italy.; h Gastroenterology and Hepatology Section, Department of Medicine , University of Perugia School of Medicine , Perugia , Italy.

DOI: 10.1080/00365521.2017.1288758

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MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Anemia, Iron-Deficiency, Anemia, Pernicious, Atrophy, Autoantibodies, Autoimmune Diseases, Diabetes Mellitus, Type 1, Enterochromaffin Cells, Enterochromaffin-like Cells, Female, Gastric Fundus, Gastritis, Helicobacter pylori, Humans, Hyperplasia, Hypothyroidism, Intestines, Italy, Male, Metaplasia, Middle Aged, Parietal Cells, Gastric, Retrospective Studies, Vitiligo, Young Adult