Endoplasmic Reticulum-Plasma Membrane Contact Sites.

Yasunori Saheki, Pietro De Camilli

Journal: Annual review of biochemistry 2017;86():659-684

PMID: 28301744

Abstract

The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). A number of protein tethers that mediate these contacts have been identified, and study of these protein tethers has revealed a multiplicity of roles in cell physiology, including regulation of intracellular Ca dynamics and signaling as well as control of lipid traffic and homeostasis. In this review, we discuss the cross talk between the ER and the PM mediated by direct contacts. We review factors that tether the two membranes, their properties, and their dynamics in response to the functional state of the cell. We focus in particular on the role of ER-PM contacts in nonvesicular lipid transport between the two bilayers mediated by lipid transfer proteins.

Address: Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore; email: [email protected].; Departments of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Kavli Institute for Neuroscience, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510; email: [email protected].

DOI: 10.1146/annurev-biochem-061516-044932

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MeSH Terms: Biological Transport, Calcium, Calcium Signaling, Carrier Proteins, Cell Membrane, Endoplasmic Reticulum, Eukaryotic Cells, Gene Expression, Homeostasis, Humans, Membrane Proteins, Neoplasm Proteins, ORAI1 Protein, Receptors, Steroid, Stromal Interaction Molecule 1, Synaptotagmins, Oxysterol Binding Proteins