Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review.

Adnan Younus, Choudhry Humayun, Rameez Ahmad, Oluseye Ogunmoroti, Yugandhar Kandimalla, Muhammad Aziz, Rehan Malik, Aisha Rasool Saand, Cyndi Valdes, Rohan Badlani, Muhammad Amir Younus, Shozab S Ali, Ye Chen, Khurram Nasir

Journal: Journal of clinical lipidology 2018;11(2):328-337

PMID: 28502488

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Abstract

BACKGROUND

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease.

OBJECTIVE

The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship.

METHODS

An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review.

RESULTS

Of the 13 studies included in the review, 6 examined the relationship between Lp-PLA2 and coronary artery calcification, of which 3 showed a significant correlation. Two studies examined the relationship between Lp-PLA2 and endothelial dysfunction, and 1 reported a significant relationship. Five studies investigated the association of Lp-PLA2 with carotid intima-media thickness (CIMT), and 3 reported a significant relationship.

CONCLUSIONS

This review shows a variable association between Lp-PLA2 and subclinical disease. This finding has broad implications for the future of public health and clinical practice. Future research is needed to clarify what role Lp-PLA2 has in guiding treatment and if it is involved in plaque instability, which would make it a useful tool for risk prognostication.

Address: Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, Miami, FL, USA.; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, Miami, FL, USA; Department of Internal Medicine, Brandon Regional Hospital, Brandon, FL, USA.; Department of Internal Medicine, Ocala Regional Medical Center, Ocala, FL, USA; Department of Internal Medicine, West Marion Community Hospital, Ocala, FL, USA.; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, Miami, FL, USA; Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, Miami, FL, USA; Department of Internal Medicine, Loyola University Medical Center, Maywood, IL, USA.; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, Miami, FL, USA; Ciccarone Preventive Cardiology Center, Johns Hopkins Hospital, Baltimore, MD, USA; Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL, USA; Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. Electronic address: [email protected].

DOI: 10.1016/j.jacl.2017.02.005

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MeSH Terms: 1-Alkyl-2-acetylglycerophosphocholine Esterase, Biomarkers, Calcium, Cardiovascular Diseases, Carotid Intima-Media Thickness, Endothelial Cells, Humans