Involvement of the NADPH Oxidase NOX2-Derived Brain Oxidative Stress in an Unusual Fatal Case of Cocaine-Related Neurotoxicity Associated With Excited Delirium Syndrome.

Stefania Schiavone, Irene Riezzo, Emanuela Turillazzi, Luigia Trabace

Journal: Journal of clinical psychopharmacology 2017;36(5):513-7

PMID: 27533346

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Abstract

Here, we investigated the possible role of the Nicotinamide Adenine Dinucleotide Phosphate oxidase NOX2-derived brain oxidative stress in a fatal case of cocaine-related neurotoxicity, associated to excited delirium syndrome. We detected a strong NOX2 immunoreactivity, mainly in cortical GABAergic neurons and astrocytes, with a minor presence in microglia, glutamatergic and dopaminergic neurons as well as a significant immunostaining for other markers of oxidative stress (8OhDG, HSP70, HSP90, and NF-κB) and apoptotic phenomena. These results support a crucial role of NOX2-derived brain oxidative stress in cocaine-induced brain dysfunctions and neurotoxicity.

Address: From the Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

DOI: 10.1097/JCP.0000000000000560

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https://medlineplus.gov/delirium.html

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MeSH Terms: Adult, Cocaine, Delirium, Fatal Outcome, Humans, Male, Membrane Glycoproteins, NADPH Oxidase 2, NADPH Oxidases, Neurotoxicity Syndromes, Oxidative Stress